Unlocking insights with AI: Multiomics analysis for target enhancer discovery
In the world of life sciences, deciphering complex biological mechanisms requires a fusion of advanced computational techniques and deep biological expertise. Our recent collaboration leveraged AI-driven bioinformatics to analyze multiomics data, identifying key regulatory elements that influence gene expression.
The challenge: Decoding gene regulation at scale
Understanding gene regulation is crucial for advancing disease research and therapeutic development. However, integrating multiple layers of omics data—such as ATAC-seq, ChIP-seq, RNA-seq, DNAse-seq, and CAGE data—to pinpoint meaningful biological signals presents a significant challenge.
Approach: AI meets bioinformatics
By combining bioinformatics analysis with deep learning models, we developed a robust workflow that:
- Aggregated multiomics data to detect key enhancers regulating gene expression.
- Applied the Enformer deep learning model, which predicts regulatory elements in a long-range sequence context.
- Identified transcription factor modulators, crucial for cell type reprogramming.
- Validated candidate targets and enhancers, feeding them into experimental pipelines for further study.
Results: AI in biological discovery
- Robust detection – Successfully identified sequence elements and proteins modulating a target gene.
- AI + bioinformatics synergy – Independent computational approaches converged on a shortlist of high-confidence candidates.
- Biological interpretation – Functional analysis and expert consultation provided a deeper understanding of the biological processes involved.
Conclusion
This AI-powered approach enables researchers to accelerate discoveries in gene regulation, helping identify potential therapeutic targets with greater accuracy. By integrating deep learning and bioinformatics, we can uncover hidden patterns in genomic data, bringing us closer to groundbreaking advancements in precision medicine.
Interested in how AI-driven multiomics analysis can support your research? Get in touch with us today!
