The History of Microbiome – the Synopsis
The Weight of Microbiome Discovery in Modern Medicine
The Promise of Immuno-Oncology in the Context of Cancer Therapy
Immunotherapy and Intestinal Microflora – the Secret Behind Successful Cancer Treatment
The Birth of Next-Generation Probiotics Market
Personalized Probiotic Treatment – Possible Future of Cancer Treatment
Perhaps personalized probiotics will become a procedure normally used in the treatment of oncological patients in the coming years and research on the microbiome will provide us with new tools to understand what it means to be human. To quote Ed Young, the author of the book “I Contain Multitudes: The Microbes Within Us and a Grander View of Life”:
‘When Orson Welles said “We’re born alone, we live alone, we die alone”, he was mistaken. Even when we are alone, we are never alone. We exist in symbiosis (…) None of those lives is lived in isolation; they always exist in a microbial context (…) we see individuals, working their way through life as a bunch of cells in a single body, driven by a single brain, and operating with a single genome. This is a pleasant fiction. In fact, we are legion, each and every one of us. Always a “we” and never a “me”. Forget Orson Welles, and heed Walt Whitman: “I am large, I contain multitudes.” ‘
Works Cited:
[1] “All About The Human Genome Project (HGP).” National Human Genome Research Institute (NHGRI), www.genome.gov/10001772/all-about-the–human-genome-project-hgp/.
[2] “Home – Genome – NCBI.” Advances in Pediatrics., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/genome.
[3] Delong, Edward F., and Norman R. Pace. “Environmental Diversity of Bacteria and Archaea.” Systematic Biology, vol. 50, no. 4, Jan. 2001, pp. 470–478., doi:10.1080/10635150118513.
[4] “’Ome Sweet ‘Omics– A Genealogical Treasury of Words.” The Scientist, www.the-scientist.com/commentary/ome-sweet-omics—a-genealogical-treasury-of-words-54889.
[5] “The Nobel Prize in Physiology or Medicine 1958.” Nobelprize.org, www.nobelprize.org/nobel_prizes/medicine/laureates/1958/.
[6] Sender, Ron, et al. “Revised Estimates for the Number of Human and Bacteria Cells in the Body.” PLOS Biology, vol. 14, no. 8, 2016, doi:10.1371/journal.pbio.1002533.
[7] I Contain Multitudes: The Microbes Within Us and a Grander View of Life. Vintage Books, 2017.
[8] Google Scholar, Google, scholar.google.pl/scholar?hl=pl&as_sdt=0,5&q=microbiome+function.
[9] Zhu, Baoli, et al. “Human Gut Microbiome: the Second Genome of Human Body.” Protein & Cell, vol. 1, no. 8, 2010, pp. 718–725., doi:10.1007/s13238-010-0093-z.
[10] Couzin-Frankel, J. “Cancer Immunotherapy.” Science, vol. 342, no. 6165, 2013, pp. 1432–1433., doi:10.1126/science.342.6165.1432.
[11] “ASCO Names Advance of the Year: Cancer Immunotherapy.” ASCO, 15 Apr. 2017, www.asco.org/about-asco/press-center/news-releases/asco-names-advance-year-cancer-immunotherapy.
[12] Gopalakrishnan, V., et al. “Gut Microbiome Modulates Response to Anti–PD-1 Immunotherapy in Melanoma Patients.” Science, vol. 359, no. 6371, Feb. 2017, pp. 97–103., doi:10.1126/science.aan4236.
[13] Roy, Soumen, and Giorgio Trinchieri. “Microbiota: a Key Orchestrator of Cancer Therapy.” Nature Reviews Cancer, vol. 17, no. 5, 2017, pp. 271–285., doi:10.1038/nrc.2017.13.
[14] Burki, Talha Khan. “Gut Microbiome and Immunotherapy Response.” The Lancet Oncology, vol. 18, no. 12, 2017, doi:10.1016/s1470-2045(17)30841-0.
[15] Matson, Vyara, et al. “The Commensal Microbiome Is Associated with Anti–PD-1 Efficacy in Metastatic Melanoma Patients.” Science, vol. 359, no. 6371, Apr. 2018, pp. 104–108., doi:10.1126/science.aao3290.
[16] Routy, Bertrand, et al. “Gut Microbiome Influences Efficacy of PD-1–Based Immunotherapy against Epithelial Tumors.” Science, vol. 359, no. 6371, Feb. 2017, pp. 91–97., doi:10.1126/science.aan3706.
[17] Patel, Jaymin, and Jason M. Crawford. “Microbiota-Regulated Outcomes of Human Cancer Immunotherapy via the PD-1/PD-L1 Axis.” Biochemistry, vol. 57, no. 6, 2018, pp. 901–903., doi:10.1021/acs.biochem.7b01249.
[18] Gopalakrishnan, Vancheswaran, et al. “The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.” Cancer Cell, vol. 33, no. 4, 2018, pp. 570–580., doi:10.1016/j.ccell.2018.03.015.
[19] O’Toole, Paul W., et al. “Next-Generation Probiotics: the Spectrum from Probiotics to Live Biotherapeutics.” Nature Microbiology, vol. 2, no. 5, 2017, doi:10.1038/nmicrobiol.2017.57.
[20] Cani, Patrice D, and Matthias Van Hul. “Novel Opportunities for Next-Generation Probiotics Targeting Metabolic Syndrome.” Current Opinion in Biotechnology, vol. 32, 2015, pp. 21–27., doi:10.1016/j.copbio.2014.10.006.
[21] Zitvogel, Laurence, et al. “The Microbiome in Cancer Immunotherapy: Diagnostic Tools and Therapeutic Strategies.” Science, vol. 359, no. 6382, 2018, pp. 1366–1370., doi:10.1126/science.aar6918