Microbiome

Decoding microbiome with Artificial Intelligence

At Ardigen, we help the pharma, biotech and academic researchers with the most challenging analysis of metagenomes. We partner with researchers to help them understand biological processes behind their data. To this end, we use a combination of data science with biology understanding. Microbiome is part of a larger biological system, that is why we focus on integrating microbial and -omics data.

Enable breakthrough discoveries with our digital microbiome solutions.

The Ardigen team has broad experience and in-depth expertise in various aspects of metagenome-related analyses – from signature discovery and time point analysis, to multi-omics, interpretability and more. What is your main challenge?

Are you facing similar challenges?

Stratification and biomarker discoveryIntegration of microbial data with other *omics or patient parametersData science with biologicalcontext understandingMicrobial target identificationMicrobiomesignature discoveryIdentification of functional traits

We are working with

  • Gut </br>Microbiome icon
    Gut
    Microbiome
  • Skin</br> Microbiome icon
    Skin
    Microbiome
  • LBP </br>design icon
    LBP
    design
  • Probiotics and </br>Nutrition icon
    Probiotics and
    Nutrition
  • Oral</br>Microbiome icon
    Oral
    Microbiome
  • Vaginal </br>Microbiome icon
    Vaginal
    Microbiome
  • Infants </br>Health icon
    Infants
    Health
  • Animal <br>Health icon
    Animal
    Health

Microbiome Transitional Platform

We solve your problems by combining our expertise into the Ardigen Microbiome Translational Platform.
Challenges in microbiome research
Ardigen Microbiome Translational Platform
Patient metagenomic and clinical data Patient metagenomic and clinical data
Exploration of functional potential
Biological findings Biological findings
Microbiome based solutions
Data

16S/Shotgun metagenomic information

Other *omics

Discovery Module

Proprietary algorithms for signature discovery

Validation Module

Rigorous validation methods, developed for metagenomic studies

Translational Module

Function discovery for bacterial proteins

  • Multi-omic time point analysis

    Integrate your MULTI-OMICS data

    Value we deliver

    Your research brought to a new dimension

     

    At Ardigen, we integrate multi-omic datasets, such as:

    • Metagenomic
    • Metabolomic
    • Clinical/meta parameters

    This enables the discovery of Multi-omic Signatures, which can be monitored in timepoints as novel data are produced.

    Microbiome Signature across timepoints Microbiome Signature across timepoints
  • Signature discovery

    SIGNATURE DISCOVERY can accelerate your product development

    Value we deliver

    Better microbiome-derived biomarkers and therapeutics development

    Most predictive taxa in the model Most predictive taxa in the model

     

     

    Ardigen Microbiome Translational Platform can easily identify bacterial signatures that contribute the most to the given host phenotype. Obtained results are generalizing for broad population.  We run analysis maintaining a high level of result credibility with the aid of thorough validation procedures.

  • Function discovery

    Bacterial FUNCTION DISCOVERY can give you many answers

    Value we deliver

    A better understanding of how bacterial proteins interact with the host cells and contribute to both health and disease.

    Validation of Functional Discovery Module

    Our Function Discovery module accurately assigned functional labels (from given databases) to proteins with experimentally confirmed functions

    Novel annotations of key metagenomic features Novel annotations of key metagenomic features

    When applied to novel protein, distinct from database entries, it enables functional understanding of microbial dark matter, in comparison to competing tools (InterProScan, Prokka)

  • Predictive modelling

    PREDICTIVE MODELLING can be understandable

    Value we deliver

    Biological discoveries derived from advanced data science.

    Advanced data science analysis

    Ardigen’s Discovery Module outcompetes standard metagenomics software in the most challenging tasks eg. prediction of cancer therapy efficacy

    Biological interpretation Biological interpretation

    We translate the predictive power of Artificial Intelligence to understand patient’s status in actual clinical cases

Our science

We are driven by science and collaborations!

Since 2015, we’ve had the opportunity to execute a variety of exciting and complex projects, both for our clients and internally.
A high degree of trust and confidentiality is the foundation for our business. That’s why we are always very excited to share the results of our scientific projects.
We publish and present materials, such as journal publications, posters, case studies and technical notes whenever possible, through which we aim to show the scope of our scientific team’s experience.

Publications

12 February 2020 Classifying bacteria clones using attention-based deep multiple instance learning interpreted by persistence homology
Download publication

    6 March 2019 Identification of Differentiating Metabolic Pathways between Infant Gut Microbiome Populations (...)
    Download publication

      Posters and case studies

      9 June 2020 Microbial signatures of response to anti-PD1 therapy in metastatic melanoma patients See the poster
      15 August 2019 Predicting response to anti-PD-1 therapy from metagenomic sequencing data with machine learning See the poster

      On demand webinars

      Microbiome meets AI
      22 April 2021 Microbiome meets AI

        The gains of microbiome studies – decoding metagenomic data
        19 March 2021 The gains of microbiome studies – decoding metagenomic data

          Squeeze the data: the modern way of decoding the microbiome
          15 October 2020 Squeeze the data: the modern way of decoding the microbiome

            Short movies and interviews

            Ardigen meets microbiome experts #2 - discussion with Martha Carlin - CEO of the BioCollective
            30 April 2021 Ardigen meets microbiome experts #2 - discussion with Martha Carlin - CEO of the BioCollective Watch the intreview
            Is there an alternative to the laborious process of discovering bacterial phenotypes?
            8 April 2021 Is there an alternative to the laborious process of discovering bacterial phenotypes? Watch the video
            Ardigen meets microbiome experts #1 - Scientific and regulatory Affairs Specialist in Microbiome
            15 March 2021 Ardigen meets microbiome experts #1 - Scientific and regulatory Affairs Specialist in Microbiome Watch the interview

            Meet us at upcoming events

            • Coming soon
              14 - 18 June
              digital
              PMWC 2021 COVID Virtual
            • 9 - 11 June
              digital
              Microbiome Data Congress
            • 10 - 11 & 14 - 18 June
              digital
              BIO Digital 2021

            Contact us

            Interested in Ardigen Microbiome based solutions?

              • https://ardigen.com/wp-content/uploads/2021/05/1@2x-1.jpg Kaja Milanowska-Zabel, PhD General Director of Microbiome Unit
              • https://ardigen.com/wp-content/uploads/2021/05/2@2x-1.jpg Agnieszka Piotrowska, PhD Alliance Manager
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