With our platform you can address the target-based Drug Discovery stages from Target Identification to Target Validation
What Distinguishes Us:
Human genetics is increasingly revealing its power in enhancing the successful drug discovery programs. The role of genetics in drug discovery and development is further supported by the increased success of drug mechanisms supported by genetic link during the course of drug development. Projects showing genetic target linkage to the disease or a stronger understanding of the role of target in the disease aetiology are less likely to fail owing to a lack of efficacy (Cook et al., Nat. Rev. Drug Discovery, 2014). The importance of human genetics is also manifested by the increasing involvement of pharmaceutical companies in genomic research projects.
What you can find inside:
Selecting the right target is a key decision early in the drug discovery process. Gene expression can de-risk drug development in early phases by identifying side-effects and indicating excessive promiscuity of drug candidates. With the costs of transcriptome profiling constantly decreasing, identification the promising drug targets that are not evenly distributed throughout the body is increasingly
affordable whether on a bulk or single cell level. The combination of orthogonal datasets provides unprecedented insights into disease biology and is informative for supporting go/no-go decisions.
Applications:
siRNAs are easy to use and established research tool used to study gene function and mechanism of action. They have become nascent therapeutics in recent years, with approved therapies against several rare diseases, along with more generic ones in line for approval. Our system allows to select siRNA molecules that are effective against chosen transcript in human and selected model organisms, thus allowing to perform the research involved in validation of the therapeutic approach using same molecule that can be later used as basis for the therapeutic. Our approach has been trusted by three commercial clients and validated experimentally.
Value We Deliver:
Since 2015, we’ve had the opportunity to execute a variety of exciting and complex projects, both for our clients and internally.
A high degree of trust and confidentiality is the foundation for our business. That’s why we are always very excited to share the results of our scientific projects.
We publish and present materials, such as journal publications, posters, case studies and technical notes whenever possible, through which we aim to show the scope of our scientific team’s experience.
